Additionally, the tumor number (HR: 2.273, P=0.016), vascular invasion (HR: 5.177, P=0.017) and PTIP expression (HR: 5.112; P=0.018) were verified as independent risk factors for disease-free survival (DFS) by both univariate and multivariate survival analysis (Table 3). The gene discussed is PAXIP1; the disease is neoplasm.