PAXIP1 and cirrhosis of liver: The tumor number (Hazard ratios (HR): 2.516 P=0.010), vascular invasion (HR: 4.154, P=0.026), liver cirrhosis (HR: 4.038, P=0.018), Edmondson-Steiner grade (HR: 3.010, P=0.031) and PTIP expression (HR: 4.980, P=0.014) were recognized as independent risk factors for overall survival (OS) by both the univariate analysis and subsequent multivariate survival analysis (Table 2).