PROM1 and glioblastoma: Wu et al. conducted a systematic review and meta-analysis to evaluate the association between CD133 or Nestin expression and the outcome of glioblastoma patients, and they found that high CDl33 expression was an independent risk factor for glioblastoma patients’ prognosis, especially WHO IV glioblastomas, and high Nestin expression was an independent risk factor for glioblastoma patients’ prognosis with grade WHO II–III [30].