Kaplan–Meier statistical analysis showed that the mean overall survival period of ObR low expression group was 4.560 ± 0.499 years, whereas that of ObR high expression group was only 2.923 ± 0.307 years, and the overall survival period of glioblastoma patients with ObR high expression was enormously shorter than that of glioblastoma patients with ObR low expression (Figure 4A, P = 0.009). This evidence concerns the gene LEPR and glioblastoma.