Moreover, there was increasing evidence suggesting a wider biological role for leptin/ObR related to tumor cell motility and invasiveness, and our data indicated that ObR-positive glioblastoma cells had a higher metastasis rate than did those with negative ObR expression, the association between ObR and GMT-related molecules expression in glioblastoma tissues was further confirmed the capabilities of ObR on tumor motility and invasion. This evidence concerns the gene LEP and neoplasm.