Expression levels of MST1, SAV1 and LATS1 mRNAs were lowly expressed in CRC tissues, compared with adjacent normal tissues by qRT-PCR test (P<0.05 for all parameters, Figure 4A, B,C), meanwhile YAP1 mRNA and protein levels were highly expressed in CRC tissues, compared with adjacent normal tissues by qRT-PCR test and immunohistochemistry (Figure 4D, E). This evidence concerns the gene SAV1 and colorectal carcinoma.