In summary, despite this limitation, the higher frequency of TB01 motifs among HESN than HIV+ subjects studied here would be consistent with the interpretation that their resistance to HIV infection is related to their NK cells having a lower activation threshold due to the presence of aKIRs whose genes map to this region and by expressing the KIR3DS1 receptor able to mediate activating signals upon interacting with HLA-F on HIV infected CD4 T cells and HLA-null 221 cells. The gene discussed is CD4; the disease is HIV infectious disease.