TGFB1 and pancreatic adenocarcinoma: A recent report has shown that silencing Nrp1 diminished TGFβ signaling in pancreatic adenocarcinoma cells, but also inhibited TGFβ1-induced Smad2 phosphorylation in endothelial cells (HUVECs) and blocked endothelial to mesenchymal transition and fibrosis [42].