The lack of direct correlation between the level of LAT1 expression and the level of intensity of [18F] FDOPA uptake in our study may be due to several reasons: sampling and intra-tumour heterogeneity, small size of our series and heterogeneity of tumours (gliomas and metastases), interferences with other factors influencing [18F] FDOPA uptake such as tumour grade [22–24] and treatments [20]. This evidence concerns the gene SLC7A5 and glioma.