We observed higher cerebral oxygenation (ΔO2 Hb) and perfusion (ΔtHb) among healthy subjects during exercise (from 50 to 100% of V ̇O2 peak) and recovery (0 to 5 min) relative to the two older groups (CHD and age-matched controls). The gene discussed is GSTM1; the disease is coronary artery disorder.