ADH5 and alcohol dependence: We believe this is the first GWAS of alcohol consumption to detect genome-wide significant association with ADH5, although a GWAS of alcohol dependence found suggestive evidence of association with PDLIM5 that is adjacent to ADH5. 12 ADH5 is a formaldehyde dehydrogenase with low affinity for alcohol and therefore its role in alcohol metabolism and consumption is as yet unknown.