Takahashi et al. [172] have reported, for example, that hepatocellular carcinoma (HCC) produces EVs and that these EVs could contain and transfer lncRNAs, among which is linc-VLDLR (very low density lipoprotein receptor); on the basis of their data, the authors speculate that linc-VLDLR, once received, is responsible for the reduced chemotherapy-induced cell death of recipient cells [172]. This evidence concerns the gene LDLR and hepatocellular carcinoma.