It would therefore be interesting in the future to determine the functional role of other ALDH isozymes in breast cancer metastasis (i.e., ALDH7A1, ALDH1A2, and/or ALDH2) [33], as well as to assess corresponding changes in genes, transcription factors, and epigenetic modifiers that may ultimately be driving the process of metastasis. This evidence concerns the gene ALDH2 and breast carcinoma.