INS and Insulin resistance: Treatment with both metformin and metformin + HCE significantly reduced the fasting blood glucose and serum insulin levels (Figure S1B,C) as well as Homeostatic Model Assessment for Insulin Resistance (HOMA-IR, Figure S1D), baseline corrected ipITT glucose area under the curve (AUC, Figure 2B), and baseline corrected OGTT glucose AUC (Figure 2D).