A liver mRNA microarray showed significant changes in the genes associated with obesity features between the control and HFS diets (Leptin receptor-Lepr, sterol regulatory element binding transcription factor 2-Srebf2, 1-acylglycerol-3-phosphate O-acyltransferase 3-Agpat3, and oestrogen receptor 1-Esr1). This evidence concerns the gene SREBF2 and obesity due to melanocortin 4 receptor deficiency.