To date, there is compelling evidence of the association of variants in the Patatin-like phospholipase domain containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2) genes, which are both involved in liver fat retention through lipid droplet remodelling and very-low density lipoprotein (VLDL) secretion, and NAFLD susceptibility and progression to NASH [119,120,121,122,123]. This evidence concerns the gene TM6SF2 and metabolic dysfunction-associated steatotic liver disease.