NR1H4 and metabolic dysfunction-associated steatohepatitis: Nevertheless, drug management of NAFLD and NASH is still far from being a successful intervention, and several novel treatments based on molecules that are able to modulate key aspects of the progression of these diseases, such as farnesoid X nuclear receptor (FXR) and peroxisome proliferator activated receptor (PPAR) activities, and chemokine receptors and immune cell metabolism are under investigation [16,17,18].