Significantly elevated levels of Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL), Tumour Necrosis Factor-α (TNF-α), and Interleukin-1 (IL-1) are frequently observed in inflamed tissues adjacent to local osteolysis compared to relevant controls in RA, periodontitis, and peri-prosthetic tissues [1,4,6,7]. The gene discussed is TNFSF11; the disease is periodontitis.