The results of the AMPLE trial confirm, in a head-to-head study, earlier findings from Abatacept or infliximab versus placebo, a Trial for Tolerability, Efficacy and Safety in Treating rheumatoid arthritis (ATTEST), which had suggested equivalent efficacy for abatacept and an anti-TNF therapy (infliximab). This evidence concerns the gene TNF and rheumatoid arthritis.