Sustained biologic-free remission after 52 weeks was also reported in patients with established RA who attained DAS28 (C-reactive protein [CRP]) <2.3 after two or more years of treatment with abatacept and was most likely in patients with lower Health Assessment Questionnaire-Disability Index (HAQ-DI) or CRP at enrollment [44]. The gene discussed is CRP; the disease is rheumatoid arthritis.