This drug is a monoclonal antibody that has a therapeutic efficacy similar to BPs, with less side effects than these, although this new drug continues to have the adverse effect of development of osteonecrosis at the level of the jaws, since its mechanism of action produces the blockade of RANKL to RANK, although due to its young age, the cases described in the literature of osteonecrosis of the jawbones are limited. The gene discussed is TNFRSF11A; the disease is osteonecrosis.