As an example, exosomes from chronic myeloid leukaemia cells were shown to require v-SNARE protein VAMP3/cellubrevin for the fusion of endosomes with autophagosomes [16], while VAMP7/TI-VAMP was required for fusion between the amphisome and lysosome. The gene discussed is VAMP3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.