CD4 and ovarian cancer: Ovarian cancer-derived EVs have been shown to promote the proliferation of CD4+CD25+FOXP3+T cells, convert CD4+CD25neg T cells into CD4+CD25+Tregs and upregulate Treg suppressor functions (e.g., production of perforin, Granzyme B, IL-10, etc.), when added to the culture of peripheral blood T cells obtained from healthy donors [102].