Indeed, similar to the mucosal chemokine CCL28 and the skin inflammation-associated cathelicidin peptide LL37 (ligand of the GPCR formyl peptide receptor 2 and others) (32), at micromolar concentrations, GPR15L has broad antimicrobial activity against different organisms, including Gram-positive Staphylococcus aureus, Actinomyce, and fungi Aspergillys niger as well as Mycoplasma and lentivirus (8). Here, GPR15LG is linked to inflammation.