IFNG and anemia: IFN-γ has been shown to be critically involved in the recruitment and activation of erythrophagocytic myeloid cells; as such IFN-γR−/− mice were partially protected against trypanosomiasis-associated inflammation and acute anemia, demonstrating a detrimental role of IFN-γ in driving enhanced erythrophagocytosis by myeloid phagocytic cells and the induction of acute inflammation-associated anemia (51).