IFNG and infection: Following infection with T. brucei rhodesiense, IFN-γ−/− C57BL/6 mice survived only 19 days, while infected wild-type cohorts were found to survive an average of 46 days; passive transfer of spleen cells from wild-type mice to IFN-γ−/− mice significantly enhanced the survival, demonstrating that IFN-γ is critical for host resistance (15).