REN and aneurysm: Hypertension could produce multiple effects as follows: (1) the wall of a formed aneurysm may be weakened due to a direct increase in mechanical stresses, (2) systemic hypertension causes activation of the local renin–angiotensin system leading to vascular inflammation and remodeling and thereby contributes to aneurysmal rupture (26), (3) reportedly, certain polymorphisms in genes related to the renin–angiotensin system are associated with aneurysm rupture (15).