As shown in Figure 8, a lower expression of phosphorylated Akt (Figures 8A,B) and Bcl-2 (Figures 8A,D), and a higher expression of Bax (Figures 8A,C) and cleaved caspase-3 (Figures 8A,E) were observed in the IH group. Here, CASP3 is linked to isolated hemihyperplasia.