The hepatic bactericidal protein hepcidin has a central role in iron metabolism, and the molecular mechanisms behind hepcidin-induced ferroportin degradation, iron sequestration in the reticuloendothelial system, hypoferremia, and iron-restricted erythropoiesis in anaemia of inflammation (AI) have been elucidated in recent years [6]. Here, HAMP is linked to anemia (phenotype).