SOX8 and alpha thalassemia spectrum: However, our ASD patients, who have alpha thalassemia trait due to 16p13.3 deletions ranging from 3,924–149,072 bp, were unlikely to have ATR-16 syndrome because the 16p13.3 deletions in previously reported patients were much larger (>800 kb)74–76 and included many other genes including SOX8.