In line with that, Genome-wide-association studies GWAS have shown the association of polymorphisms in the Prdm1 gene and IBD15 and other chronic inflammatory conditions in humans, including Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE)16. This evidence concerns the gene PRDM1 and systemic lupus erythematosus.