In contrast, if the cut-off value was set at 2.025 mg/L for distinguishing between IMN and other renal diseases, serum anti-PLA2R-IgG levels in patients with IgA nephropathy, lupus nephritis, minimal change disease, and other renal diseases were all lower than the threshold, while 49 of 69 patients with IMN were positive. This evidence concerns the gene PLA2R1 and lupus nephritis.