SLC1A2 and schizophrenia: This protein binds EAAT2, regulating its surface trafficking via a leucine zipper-like motif.174 In addition, glycosylation of EAAT2 is significantly reduced in schizophrenia, a posttranslational modification that is involved in molecular trafficking.175,176 Interestingly, increased levels of EAAT2b, but not EAAT2a or EAAT2 exon9skipping protein isoforms, were identified in the extrasynaptic membrane fraction in schizophrenia.142