Similar to findings in ALS, EAAT2b mRNA is increased in excitatory neurons in schizophrenia, including relay neurons in the mediodorsal thalamic nucleus and pyramidal neurons in the ACC.195,197 While the functional role of EAAT2b expression in neurons remains to be determined, it is tempting to predict that an increase in neuronal EAAT2b, rather than EAAT2a expression, increases localization of EAAT2b-containing isoforms of the EAAT2 protein complex near or at presynaptic or postsynaptic terminals. This evidence concerns the gene SLC1A2 and schizophrenia.