For example, altered EAAT2 expression in Alzheimer’s dementia is likely secondary to the gross structural changes in the brain, resulting from the massive loss of neurons associated with disease.204 In contrast, more subtle changes in EAAT2 expression are found in schizophrenia, which typically has a small reduction in astrocyte numbers with no change in the number of pyramidal neurons.4 Here, SLC1A2 is linked to Alzheimer disease.