This suggests an increased potential for glutamate release that may facilitate the role of clozapine in potentiation of the excitatory synapse.171 Overall, pharmacological (PCP) and behavioral (PPI) paradigms that are associated with the symptoms of schizophrenia implicate not only glutamate receptor dysregulation in schizophrenia, but other proteins related to glutamate transmission, including EAAT2. Here, SLC1A2 is linked to schizophrenia.