The pooled ORs from the overall studies suggested noassociation with increased or decreased risk between TNF -308G>A gene polymorphism and leprosy risk in allelic contrast (A vs. G:P=0.068; OR = 0.836, 95% CI =0.689–1.013), homozygous (AA vs. GG: P=0.394; OR= 0.810, 95% CI = 0.499–1.315), heterozygous (GA vs.GG: P=0.059; OR = 0.780, 95% CI =0.603–1.010), dominant (AA + GA vs. GG: P=0.067;OR = 0.797, 95% CI = 0.625–1.016), and recessive (AAvs. The gene discussed is TNF; the disease is leprosy.