Effector memory Th1 CD4 T cells confer partial protection in the self‐resolutive Plasmodium chabaudi chabaudi (Pcc) model (Stephens & Langhorne, 2010), and loss of T‐bet, a master regulator of Th1 differentiation, impairs control of parasitemia in the Plasmodium berghei ANKA (PbA) model (Oakley et al, 2013). This evidence concerns the gene CD4 and parasitic infectious disease.