CD4 and infection: This vaccine strain, in which the sequences of all identified peptides are conserved (Otto et al, 2014), causes self‐resolving blood‐stage infection and results in long‐lasting cross‐stage and cross‐species immunity (Demarta‐Gatsi et al, 2016). Three weeks post‐challenge with Pb NK65 ΔHRF, we could detect CD4 T cells reactive against 11 of the identified peptides (Fig EV2C).