Although signatures and cell composition from sIU and sIA patients were comparable to those of healthy controls, sAU patients displayed a proinflammatory signature enriched for IL-1β–inducible transcripts (IL1B and CASP1) and demonstrated leukocytosis, neutrophilia, and monocytosis (Fig. 4, B and C). Here, CASP1 is linked to Increased total leukocyte count.