DKK1 and dyschromatosis symmetrica hereditaria: Dkk-1 concentrations were significantly higher in RAD (median 3.42 ng/mL; IQR 2.75, 4.49) compared with non-RAD (median 3.03 ng/mL; IQR 1.93, 3.69) cases (ORadj 1.22 per ng/mL increase; 95% CI 1.05, 1.42; p = 0.01) (Table 3).