Using the same cohort and comparator samples from patients with psoriasis only (cases) and matched healthy controls, the aims of this study were to confirm and determine if these four biomarkers (Dkk-1, M-CSF, MMP-3, and OPG): (i) are associated with PsA; (ii) differentiate patients with psoriasis with and without arthritis; and (iii) differentiate patients with PsA with and without axial arthritis. Here, MMP3 is linked to arthritic joint disease.