MAPT and tauopathy: According to the pathology, we divide tauopathies into three main groups: tauopathies associated with the deposition-predominant tau pathology composed mainly of abnormal deposition of tau into intracellular neurofibrillary tangles, tauopathies associated with the deposition of amyloid beta (Aβ), and tauopathies associated with other pathologies [1].