The SHR72 Tg rat model recapitulates many features seen in AD and other tauopathies, including tau hyperphosphorylation and truncation, formation of neurofibrillary tangles located in the brainstem, insoluble tau complexes [4], white matter damage [5], increased reactive oxygen species, and mitochondrial damage [6, 7]. The gene discussed is MAPT; the disease is Alzheimer disease.