Consistent with our data, the Nephroseq online database demonstrates a lower expression of glomerular Esm-1 in individuals with DN vs. healthy human donors, and serum Esm-1 is lower in individuals with diabetes mellitus (1.75 ± 0.78 ng/mL) vs. healthy controls (2.20 ± 0.54 ng/mL)[51], although the susceptibility to DN is not known. This evidence concerns the gene ESM1 and diabetes mellitus.