ADSL and graft versus host disease: The strong impact of early 3-IS levels however also raises the possibility that early loss of commensals (induced by cytotoxic conditioning, SNPs of innate immunity, broad spectrum antibiotics) facilitates Paneth cell destruction (e.g. via loss of epithelial protection by IL22 [26] and loss of AMPs which further enhances GvHD and a vicious circle of microbiota damage.