While current mouse models such as the LSL-KrasG12D/+;LSL-p53R172H/+;Pdx-1-Cre (KPC) model accurately reflect the genetics of pancreatic tumor cells and human tumor progression [6–8], these models depend on epithelial-specific Cre-mediated recombination to drive tumorigenesis. This evidence concerns the gene PDX1 and pancreatic neoplasm.