Among the three treated groups, anti-tumor inhibition of Gem-TSLnps + mHT (at Gem equivalent dose of 10 mg/kg) treated group was significantly increased when compared with Gem (at Gem dose of 20 mg/kg) and Gem-TSLnps (at Gem equivalent dose of 10 mg/kg), implying that the anti-tumor activity of Gem was improved through the delivery system of TSLnp combined with mHT. Here, GEM is linked to neoplasm.