In addition, one pharmacological study has also demonstrated that the D2R antagonism, in symptomatic R6/2 mice, attenuated response of immediate early genes including c-Fos, while the D1R agonism produced rather similar or enhanced striatal responses, suggesting clear differences in functional integrity between the direct and indirect pathway MSNs in HD mice [32]. The gene discussed is DRD1; the disease is Huntington disease.