The majority of postmenopausal breast cancer is early stage or localized (i.e., lymph node-negative) at diagnosis, and the extended anti-estrogen therapy (i.e., aromatase inhibitors) is the primary adjuvant therapy, which may pose additional long-term risks of CVD, especially to older postmenopausal patients [17–19,28–30]. Here, CYP19A1 is linked to breast carcinoma.