CD4 and cytomegalovirus infection: This increase in the humoral response, along with its association with the nadir CD4+ T-cell count, CD4+ T-cell activation, sCD14 and cell death, suggest that CMV infection with likely persistent periods of subclinical reactivation could be a relevant driving force in inflammation and immune activation, and therefore, may impact the mortality observed in HIV+ individuals with poor CD4+ T-cell recovery.