IL6 and inflammatory bowel disease: Tocilizumab, a recombinant humanized monoclonal antibody of the IgG1 subclass directed against soluble and membrane bound IL-6 is currently licensed for use in several rheumatic conditions and has been used successfully in pilot studies and case reports in IBD patients, however concerns have been raised regarding a higher rate of intestinal perforation associated with the use of Tocilizumab [100,101,102].