Consistent with our results, another study found that PINK1 transcription was upregulated in Thy-1 α-syn transgenic mice as compared to wild-type mice.27 Moreover, PINK1 protein level was increased in α-syn transgenic mice treated with Rot, a pesticide that is used for animal models of PD, indicating that α-syn overexpression may stimulate endogenous PINK1 as a compensatory response to cellular stress.28 This evidence concerns the gene PINK1 and Parkinson disease.