It was previously reported that α-syn overexpression decreased cell viability and caused behavioral deficits in PD models, effects that were abrogated by PINK1.13, 14, 15 Many studies have reported that α-syn localizes to and impairs mitochondrial function.7, 24, 25 In the present study, we found that PINK1 mainly interacted with α-syn in the cytoplasm, preventing it from associating with mitochondria. The gene discussed is PINK1; the disease is Parkinson disease.