T. cruzi is a unicellular protozoan parasite that infects 7–8 million people in South America as well as in other parts of the world through migrations from endemic areas.6 The T. cruzi infection can evolve into Chagas disease, a potential life-threatening illness.7 Our research group has described the T. cruzi CyP gene family and reported the expression of several parasite cyclophilins that exhibited enzymatic PPIase activity, inhibited by CsA.8 The gene discussed is PPIB; the disease is Chagas disease.