As showed in Figure 7c, WP1130 suppressed the transcription of CCND2, ITGB7 and ARK5, downstream genes under c-Maf control,2, 4 particularly at a concentration of 5 μM. Consistent with this finding, when USP5 was knocked down in these MM cells, the specific RNA of all three genes were suppressed. Here, NUAK1 is linked to Miyoshi myopathy.