As showed in Figure 7c, WP1130 suppressed the transcription of CCND2, ITGB7 and ARK5, downstream genes under c-Maf control,2, 4 particularly at a concentration of 5 μM. Consistent with this finding, when USP5 was knocked down in these MM cells, the specific RNA of all three genes were suppressed. This evidence concerns the gene CCND2 and Miyoshi myopathy.