Similarly, we also observed the attenuated hepatic steatosis and the decrease of SREBP1c, Pparγ, Scd1 and Cd36 involved in lipogenesis and lipid uptake, and increase of Cpt1, Acat and Echs1 involved in fatty acid oxidation in the liver of mice fed HFD and hemin. The gene discussed is ECHS1; the disease is fatty liver disease.