RUNX1 and acute myeloid leukemia: Other significant associations, such as with alterations in the tyrosine kinase FLT3, splicing factor mutations, or isocitrate dehydrogenase (IDH1 or IDH2) has not been firmly established [3,4,7,10]; however, concomitant FLT3 mutations are thought to play a synergistic role with RUNX1 mutations in the development of AML [11].