In the current study, we found that mollugin inhibited the TNF-α-induced expression of anti-apoptotic proteins such as cIAP-1, Bcl-2, and survivin, which are regulated by NF-κB, and their overexpression in many tumors has been associated with tumor cell survival, chemoresistance, and radioresistance. This evidence concerns the gene NFKB1 and neoplasm.