FGF2 and malignant colon neoplasm: Hesperetin supplementation of rats, at 20 mg/kg, has been reported to decrease 1,2-dimethylhydrazine-induced formation of angiogenic growth factors, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and EGF, in experimental colon cancer [68].