Along with Nrf2 induction, I3C and its derivatives exhibit chemopreventive bioactivity through a number of other mechanisms, including suppression of proliferation of cancer cells from various tissues through regulatory repression of cyclin-dependent kinases, induction of apoptosis, and modulation of expression of several transcription factors (reviewed by Aggarwal and Ichikawa [153]). The gene discussed is NFE2L2; the disease is cancer.