TNF and colorectal cancer: In fact, chronic inflammation constitutes a major risk for colorectal cancer [6,7,33], and most inflammation-associated colorectal cancers retain the activation of the transcription factor nuclear factor-kappa B (NF-ĸB) and inflammatory mediators (tumor necrosis factor (TNFα), cyclooxygenase-(COX)-2, etc.), all of these markers being related to cell proliferation, anti-apoptotic activity, angiogenesis and metastasis [6].