Chen et al. showed, in a comparative study with 25 AFD patients with LVH under 12 months of ERT, 25 AFD patients without LVH and 25 healthy controls, a significant improvement in the transthoracic echocardiography parameters (left ventricular mass (LVM), LVM index (LVMI), interventricular septal thickness), in the Lyso-Gb3 and pro-inflammatory cytokine levels (interleukin (IL)-6, IL-2, IL-1b, tumour necrosis factor-α, intercellular adhesion molecules, soluble vascular cell adhesion molecule, and monocyte chemoattractant protein 1 (MCP-1)) after ERT. This evidence concerns the gene IL2 and Nager acrofacial dysostosis.