FTO expression is not only controlled by the nucleotide sequence but also by epigenetic regulation of FTO. Continued uptake of milk-derived exosomes that carry DNMT-targeting miRNAs may represent an overlooked mechanism that modifies early programming of the human epigenome promoting FTO-driven food intake and the development of diseases of civilization such as diabesity, allergy, neurodegenerative diseases, and cancer [135]. The gene discussed is FTO; the disease is allergic disease.